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Charlotte Ling, Professor of Epigenetics at Lund University, is receiving DKK 10 million from the Novo Nordisk Foundation for a research project relating to epigenetics and type 2 diabetes. She is one of a total of 38 research group leaders who are receiving funding through the Novo Nordisk Foundation’s Research Leader Programme. The project is called “Pancreatic islet dysfunction and epigenetic m

https://www.medicine.lu.se/article/charlotte-ling-receives-million-dollar-grant-novo-nordisk-foundation - 2025-11-11

A new app will make it easier for people on sick leave due to anxiety and depression to get back to work. In the project mWorks, Professor Ulrika Bejerholm and her research colleagues focus on what strengths, abilities and new strategies can help people on sick leave successfully transition back to working life. The research team wishes to move away from the current focus on diagnosis and disabili

https://www.medicine.lu.se/article/new-app-help-people-return-work-following-sick-leave-due-mental-illness - 2025-11-11

Researchers at Lund University in Sweden have developed an algorithm that combines data from a simple blood test and brief memory tests, to predict with great accuracy who will develop Alzheimer's disease in the future. The findings are published in Nature Medicine. Approximately 20-30% of patients with Alzheimer's disease are wrongly diagnosed within specialist healthcare, and diagnostic work-up

https://www.medicine.lu.se/article/simple-diagnostic-tool-predicts-individual-risk-alzheimers - 2025-11-11

Many people feel mentally unwell during the pandemic, especially, it seems, those who are already exposed to socio-economic inequalities. But who really suffers the most when restrictions, loneliness, depression have become commonplace? Researchers from Lund University have tried to find out in a cross-sectional study where young adults are identified as a particularly vulnerable group. After more

https://www.medicine.lu.se/article/how-vulnerable-are-we-pandemic-and-who-actually-hardest-hit - 2025-11-11

Children rarely get seriously ill in COVID-19. However, they can suffer from troublesome secondary diseases, the most serious being MIS-C, a hyper-inflammatory condition that often requires intensive care. In Skåne, around 30 children have been affected by MIS-C. Skåne University Hospital is leading the work to care for the affected children and research is also underway on the disease. MIS-C is a

https://www.medicine.lu.se/article/new-research-skane-university-hospital-shed-light-mis-c - 2025-11-11

An international group of clinicians and scientists, including MIT and Lund University , have analysed how individual genetic changes affect the heart muscle. The researchers have created a new computer tool to integrate genomic and clinical data to enhance medical and surgical decisions to support future therapies for patients with inherited heart disease. The new research was published in NPJ Ge

https://www.medicine.lu.se/article/computer-method-help-predict-outcomes-and-tailor-treatments-heart-patients - 2025-11-11

Cardiovascular and lung disease increase the risk of complications in COVID-19. Therefore, the Heart-Lung Foundation has granted SEK 3.1 million for five research projects at Lund University that will contribute to more knowledge about the effects of COVID-19. One of the researchers, Jonas Erjefält, professor in Medical Inflammation, has been granted SEK 1 million for mapping of immunological dise

https://www.medicine.lu.se/article/five-lund-researchers-received-grants-deepen-knowledge-about-effects-covid-19 - 2025-11-11

Newborn babies are already being screened for mutations and genetic tests help families with hereditary breast cancer. Genomic-driven precision medicine (GDPM) is an emerging approach for disease treatment. Around 30 Swedish researchers suggest a direction forward in a review article in Journal of Internal Medicine (JIM). "At the moment newborns are screened for a small number of mutations. In the

https://www.medicine.lu.se/article/precision-medicine-emerging-approach-complex-diseases - 2025-11-11

To counter the effects of antibiotics, bacteria constantly evolve resistance mechanisms. In order to develop new antibiotics that could overcome the resistance, it´s essential to understand its workings. Using so-called cryogenic electron microscopy (cryo-EM) researchers at Lund and Hamburg universities have uncovered the molecular details of an important antibiotic resistance mechanism. This is t

https://www.medicine.lu.se/article/nobel-prize-winning-microscopy-technique-uncovers-mechanisms-bacterial-antibiotics-resistance - 2025-11-11

First-born children are at lower risk of heart attack and stroke than their siblings – provided that the number of siblings does not exceed three; then it is the other way around. And people without siblings have a higher risk of heart attack and stroke later in life compared to those who have siblings. These are among the findings of a new population study from Lund University published in BMJ Op

https://www.medicine.lu.se/article/number-siblings-may-be-linked-risk-cardiovascular-disease - 2025-11-11

Up to 20 percent of Swedish couples have difficulty having children. Now a new research project will seek to find the answer to the riddle of infertility. In a group effort to combat involuntary childlessness, researchers within the Öresund collaboration ReproUnion are creating a register that includes 5,000 Swedish and Danish childless couples. The biobank is named ReproUnion Biobank and Infertil

https://www.medicine.lu.se/article/reprounion-joins-forces-combat-involuntary-childlessness-creating-biobank - 2025-11-11

New population study from Lund University Risk of bladder cancer by disease severity in relation to metabolic factors and smoking; a prospective pooled cohort study of 800,000 men and womenPrevious studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor invasiveness. Among 811 63

https://www.lupop.lu.se/article/risk-bladder-cancer-disease-severity-relation-metabolic-factors-and-smoking - 2025-11-11

Registries are one way to provide longitudinal, observational data, giving rise to a range of possibilities in terms of audit and research. They allow examining approaches to management, which would not be feasible by a trial or where there was no trial data (currently or likely ever) available. In this Perspective, we will discuss aspects of their design, analysis, and use in the field of pain. R

https://www.lupop.lu.se/article/perspectives-pain-registries - 2025-11-11

Epidemiologists commonly use an adjusted hazard ratio or incidence density ratio, or a standardized mortality ratio, to measure a difference in all-cause mortality rates. They seldom translate it into an age-, time-, or probability-based measure that would be easier to communicate and to relate to. Several articles have shown how to translate from a standardized mortality ratio or hazard ratio to

https://www.lupop.lu.se/article/translating-all-cause-mortality-rate-ratios-or-hazard-ratios-age-longevity-and-probability-based - 2025-11-11

Results of randomized trials and observational studies can be difficult to communicate. Results are often presented as risk or survival functions stratified by the treatment or exposure (1, 2). However, a contrast between the stratified risk functions is often of primary interest. Here we propose a “twister” plot to visualize contrasts in risk over the duration of a study. The twister plot is a −9

https://www.lupop.lu.se/article/twister-plots-time-event-studies - 2025-11-11

Psychosocial constructs can only be assessed indirectly, and measures are typically formed by a combination of indicators that are thought to relate to the construct. Reflective and formative measurement models offer different conceptualizations of the relation between the indicators and what is sometimes conceived of as a univariate latent variable supposed to correspond in some way to the constr

https://www.lupop.lu.se/article/constructed-measures-and-causal-inference-towards-new-model-measurement-psychosocial-constructs - 2025-11-11

Mendelian randomization (MR) is often used to estimate effects of time-varying exposures on health outcomes using observational data. However, MR studies typically use a single measurement of exposure and apply conventional instrumental variable (IV) methods designed to handle time-fixed exposures. As such, MR effect estimates for time-varying exposures are often biased, and interpretations are un

https://www.lupop.lu.se/article/mendelian-randomization-repeated-measures-time-varying-exposure - 2025-11-11

Lifetime risk measures the cumulative risk for developing a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the competing risk of death, and inference at a fixed age. In addition, statistical methods to predict the lifetime risk should account for covariate-outcome associations that change with age. In this paper, we review and compare statistical methods

https://www.lupop.lu.se/article/comparison-statistical-methods-predict-residual-lifetime-risk - 2025-11-11

The Diet, Cancer and Health—Next Generations (DCH-NG) study is a large population-based cohort study that was established as a resource for transgenerational research. The cohort is an extension of the Diet, Cancer and Health (DCH) cohort. The aim of this paper was to describe the study design and methods and to investigate the representativeness of participants by comparing participants with non-

https://www.lupop.lu.se/article/cohort-profile-and-representativeness-participants-diet-cancer-and-health-next-generations-cohort - 2025-11-11

Karin Larsson's presentation from the GIS seminar is now available Read more here.

https://www.lupop.lu.se/article/what-gis-and-what-can-it-be-used - 2025-11-11